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pentobarbital will decrease the extent or impact of efavirenz by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.pentobarbital improves effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Check. Coadministration of ifosfamide with CYP2B6 inducers might maximize metabolism of ifosfami